Related Experiment Video
Updated: Feb 8, 2026

Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
An abnormal fibrinogen (Copenhagen II) with increased sialic acid content associated with thrombotic tendency and
Abstract:
An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease. A qualitatively abnormal fibrinogen was detected in the plasma of a 25-year-old man with a thrombotic tendency. The purified fibrinogen had a significantly increased content of sialic acid, an abnormal fibrin monomer polymerization, and a changed mobility in crossed affinity-immunoelectrophoresis using immobilized helix pomatia lectin. The patient had no biochemical or clinical signs of liver disease. The occurrence of a thrombotic tendency and an increased fibrinogen sialic acid content without signs of liver disease may represent a new variant of congenital dysfibrinogenaemia.
Related Concept Videos
Increasing Function
Measures of Central Tendency
What is Central Tendency?
The central tendency is the most conventionally used data characteristic. It is a...
Central Tendency: Analysis
The mean is one such measure, calculated by totaling all values in a dataset and dividing by the number of values. For instance, the mean blood pressure reading (120, 130, 140, 150) would be 135. However, the mean can be affected by extreme values or outliers.
The median, another measure,...
Abnormal Proliferation
Ions as Acids and Bases
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:

