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Fibrin-derived vasoactive peptides release histamine.

M Eriksson, K Saldeen, T Saldeen

    International Journal of Microcirculation, Clinical and Experimental
    |January 1, 1983
    PubMed
    Summary

    Two fibrin peptides increase microvascular permeability by releasing histamine. This effect, crucial for inflammation, can be blocked by antihistamines, highlighting histamine

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    Area of Science:

    • Biochemistry
    • Physiology
    • Pharmacology

    Background:

    • Fibrin-derived peptides are known to influence vascular function.
    • Microvascular permeability is a key indicator of inflammatory processes.
    • Histamine is a well-established mediator of increased vascular permeability.

    Purpose of the Study:

    • To investigate the mechanism by which two specific fibrin-derived peptides (Ala-Arg-Pro-Ala-Lys and Ser-Gln-Leu-Gln-Lys-Val-Pro-Pro-Glu-Trp-Lys) affect microvascular permeability.
    • To determine the role of histamine release in the observed effects of these peptides.
    • To compare the mechanism of these peptides with other known permeability-increasing peptides.

    Main Methods:

    • Administration of fibrin-derived peptides to rat skin.
    • Measurement of microvascular permeability.
    • Assessment of histamine release from rat mast cells.
    • Inhibition studies using histamine depletion and an H1-blocker (mepyramine maleate).

    Main Results:

    • The two fibrin-derived peptides significantly increased microvascular permeability in rat skin.
    • These peptides were shown to induce histamine release from rat mast cells.
    • The increase in microvascular permeability caused by the peptides was significantly reduced by prior histamine depletion and by treatment with mepyramine maleate.

    Conclusions:

    • Histamine release is a significant contributing factor to the microvascular permeability-increasing effects of these fibrin-derived peptides.
    • The mechanism of action for these peptides is similar to that of bradykinin, substance P, and neurotensin, involving histamine release.
    • These findings elucidate a key inflammatory pathway mediated by fibrin-derived peptides.

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