Related Experiment Video

Updated: Oct 21, 2026

Establishment and Characterization of UTI and CAUTI in a Mouse Model
08:40

Establishment and Characterization of UTI and CAUTI in a Mouse Model

Published on: June 23, 2015

[Relation between the O:K:H serotype and the fimbria antigen in E. coli of urinary tract infections]

W Nimmich, G Zingler

    Zeitschrift Fur Urologie Und Nephrologie
    |June 1, 1984
    PubMed

    Insights

    This study links specific E. coli fimbrial antigens (F-antigens) to urinary tract infections (UTI). Researchers identified F9 and F11 antigens in E. coli strains, correlating them with O:K:H serotypes and mannose-resistant hemagglutination patterns.

    Area of Science:

    • Microbiology
    • Immunology
    • Infectious Diseases

    Background:

    • Urinary tract infections (UTI) are often caused by Escherichia coli (E. coli).
    • E. coli virulence is associated with specific O:K:H serotypes and adhesive factors like fimbriae.
    • Fimbriae play a crucial role in the pathogenesis of UTI by facilitating bacterial adhesion.

    Purpose of the Study:

    • To investigate the relationship between E. coli O:K:H serotypes, fimbrial (F) antigens, and hemagglutination (HA) patterns in strains causing UTI.
    • To identify specific fimbrial antigens associated with particular E. coli serotypes found in UTI patients.

    Main Methods:

    • Examined 42 O1:K2 E. coli strains from UTI patients.
    • Assessed mannose-resistant hemagglutination (HA) patterns using human and monkey erythrocytes.
    • Utilized crossed immunoelectrophoresis to identify fimbrial (F) antigens.
    • Correlated HA patterns and F-antigens with O:K:H serotypes.

    Main Results:

    • 31 strains exhibited mannose-resistant HA, which correlated with the presence of specific F-antigens.
    • Identified F11 antigen in twelve O1:K1:H7 strains and their immobile variants.
    • Detected F9 antigen in 14 strains of the O1:K1:H- serotype.
    • Found a strong association between O:K:H serotypes and F-antigen expression.

    Conclusions:

    • Specific E. coli fimbrial antigens (F9 and F11) are closely linked to particular O:K:H serotypes.
    • O1:K1:H7:F11 (including immobile variants) and O1:K1:H-:F9 strains likely originate from distinct bacterial clones.
    • Fimbrial antigen profiling is valuable for understanding E. coli pathogenesis in UTI.

    More Related Videos

    Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis07:34

    Isolation of Single Intracellular Bacterial Communities Generated from a Murine Model of Urinary Tract Infection for Downstream Single-cell Analysis

    Published on: April 16, 2019

    Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing09:44

    Characterization of a Pathogenic Escherichia coli Strain Derived from Oreochromis spp. Farms Using Whole-Genome Sequencing

    Published on: December 23, 2022

    Related Concept Videos

    Urinary Tract Infection I: Introduction01:26

    Urinary Tract Infection I: Introduction

    Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
    Fimbriae, Pili, and Axial Filaments01:28

    Fimbriae, Pili, and Axial Filaments

    Fimbriae and pili are specialized bacterial surface structures that play pivotal roles in adhesion, genetic exchange, and motility. Composed primarily of pilin protein, these hairlike appendages are crucial for bacterial survival and pathogenicity in various environments.Fimbriae: Adhesion and PathogenicityFimbriae are fine, filamentous structures measuring 2–10 nanometers in diameter and are densely distributed on the bacterial cell surface. They facilitate bacterial adhesion to abiotic...
    Conjugation01:19

    Conjugation

    Conjugation is a form of horizontal gene transfer that primarily occurs in bacteria and some archaea, promoting genetic diversity and adaptation. Bacteria can acquire resistance genes through conjugative plasmids, allowing them to survive antibiotic treatments that would otherwise be lethal. This process involves direct contact between cells through specialized structures such as the sex pilus and is mediated by conjugative plasmids, including the F (fertility) factor.Conjugation requires...
    Microbiota of the Urogenital Tract01:28

    Microbiota of the Urogenital Tract

    The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
    Bacterial Gastroenteritis01:18

    Bacterial Gastroenteritis

    Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
    Cholera01:25

    Cholera

    Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...