Effect of interferon and polyvalent bacterial vaccine on histamine release from sensitized mouse mastocytes

The present paper discusses the correlation between NDV-induced interferon production and the degree of histamine release from mouse mastocytes. The injection of mice with Newcastle virus was observed to substantially increase the percentage of released histamine and the degree of mastocytes degranulation. A clear-cut correlation was observed between virus-induced interferon titer and the degree of histamine release both in nonsensitized (control) as well as in sensitized mice. In sensitized animals, however, interferon titer, the percentage of histamine release and degree of mastocytes degranulation was higher. Polyvalent bacterial vaccine was shown to exert the inhibitory effect on the production of interferon induced both in sensitized and nonsensitized mice, however, its influence on the amount of histamine released was not confirmed.