The mechanisms underlying potentiation of recruiting responses may include GABA-disinhibition

Potentiation of recruiting responses has been demonstrated to occur in the course of development of generalized epilepsy in the cat (Kostopoulos and Avoli 1983). A similar potentiation of RR of cortical neurons was demonstrated here after microiontophoretic application of bicuculline. The release of cortical neurons from a GABA-mediated inhibition or another mechanism more sensitive to bicuculline may underly both these phenomena.