Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The CRF neuron: immunocytochemical study.

D Fellmann, C Bugnon, J L Bresson

    Peptides
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The rostromedial zona incerta is involved in attentional processes while adjacent LHA responds to arousal: c-Fos and anatomical evidence.

    Brain structure & function·2017
    Same author

    Measurement of the charge asymmetry in top quark pair production in <i>pp</i> collisions at [Formula: see text] using the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for lepton flavour violation in the <i>eμ</i> continuum with the ATLAS detector in [Formula: see text]<i>pp</i> collisions at the LHC.

    The European physical journal. C, Particles and fields·2015
    Same author

    Measurement of [Formula: see text] production with a veto on additional central jet activity in <i>pp</i> collisions at [Formula: see text] TeV using the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same author

    Measurement of the top quark mass with the template method in the [Formula: see text] channel using ATLAS data.

    The European physical journal. C, Particles and fields·2015
    Same author

    Search for heavy neutrinos and right-handed <i>W</i> bosons in events with two leptons and jets in <i>pp</i> collisions at [Formula: see text] with the ATLAS detector.

    The European physical journal. C, Particles and fields·2015
    Same journal

    Potential role of intelectin-1 in the regulation of feeding of goldfish (Carassius auratus).

    Peptides·2026
    Same journal

    Cocaine- and amphetamine-regulated transcript (CART) peptides: Neuroanatomical distribution and functional implications in the mammalian central nervous system.

    Peptides·2026
    Same journal

    P1642-1, a novel pancreatic polypeptide analogue, ameliorates cognitive impairment in 5 ×FAD mice and is associated with enhanced PINK1/Parkin-related mitophagy.

    Peptides·2026
    Same journal

    Structure-based rational design of high-affinity JAZF1 variants peptides to target the testicular orphan nuclear receptor 4 and pro-opiomelanocortin axis in Cushing's disease.

    Peptides·2026
    Same journal

    [Gly<sup>2</sup>]-GLP-2(1-5): An ultra-short GLP-2 peptide for intestinal mucosal protection in inflammatory bowel disease.

    Peptides·2026
    Same journal

    The role of Kiss1 neurons in regulating metabolism and energy balance.

    Peptides·2026
    See all related articles

    This study maps corticotropin-releasing factor (CRF) in vertebrate brains, revealing its role in stress response and pituitary control across species. CRF systems show species-specific adaptations and are regulated by corticosteroids and catecholamines.

    Area of Science:

    • Neuroendocrinology
    • Comparative Neuroscience
    • Immunocytochemistry

    Background:

    • Corticotropin-releasing factor (CRF) is a key neurohormone regulating the stress response.
    • CRF neurons form a prominent hypothalamo-infundibular system controlling the pituitary gland.
    • CRF also functions in extrahypothalamic interneurone systems within the brain.

    Purpose of the Study:

    • To investigate the distribution and adaptations of CRF-containing neurons and fibers across diverse vertebrate species.
    • To explore the regulation of CRF in the median eminence (ME) by corticosteroids and catecholamines.
    • To determine the developmental timeline of the CRF system in relation to pituitary corticotrophs.

    Main Methods:

    • Immunocytochemical staining using an antiserum to ovine CRF 41.

    Related Experiment Videos

  • Adrenalectomy and dexamethasone replacement therapy in rats.
  • Reserpine administration and monoamine oxidase inhibitor (MAOI) pretreatment in rats.
  • Fetal developmental studies in humans and rats.

    • Main Results:

    • CRF perikarya, fibers, and terminals were identified in various brain regions across mammals, birds, reptiles, amphibians, and fish.
    • CRF innervation of the median eminence (ME) and its homologous structures varies across species.
    • CRF immunoreactivity in the rat ME showed a biphasic response to adrenalectomy, modulated by dexamethasone.
    • Catecholamines were found to inhibit CRF release in the ME.
    • The CRF system develops postnatally in rats and late in human fetal development.

    Conclusions:

    • The CRF system exhibits significant species-specific adaptations in its neuronal organization and function.
    • CRF plays a conserved role in pituitary control and stress response across vertebrates.
    • CRF release is under complex regulation by corticosteroids and catecholamines.
    • The developmental timing of the CRF system suggests a coordinated maturation with the pituitary-adrenal axis.