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Related Experiment Videos

Ethambutol-induced hyperuricaemia.

B K Khanna, V P Gupta, M P Singh

    Tubercle
    |September 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Ethambutol in tuberculosis treatment can cause hyperuricemia, leading to joint pain and gout in some patients. Monitoring uric acid levels is crucial during ethambutol therapy.

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    Area of Science:

    • Pharmacology
    • Clinical Medicine
    • Rheumatology

    Background:

    • Pulmonary tuberculosis treatment often involves multiple drugs.
    • Ethambutol is a key component in some tuberculosis regimens.
    • Hyperuricemia is a potential adverse effect of certain medications.

    Observation:

    • A prospective study compared ethambutol-containing regimens (SHE) with non-ethambutol regimens (SHT) in 134 pulmonary tuberculosis patients.
    • Patients were hospitalized and received either streptomycin, isoniazid, and ethambutol (SHE) or streptomycin, isoniazid, and thioacetazone (SHT).

    Findings:

    • A significant increase in serum uric acid levels (hyperuricemia) was observed in 66% of patients receiving ethambutol (SHE group) within 60-90 days.
    • No significant change in uric acid levels was noted in the thioacetazone group (SHT).

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  • Two patients on ethambutol developed arthralgia and acute gouty arthritis, which resolved upon ethambutol withdrawal and recurred upon reintroduction.

    • Implications:

    • Ethambutol therapy is associated with a high incidence of hyperuricemia in tuberculosis patients.
    • Clinicians should monitor serum uric acid levels in patients treated with ethambutol.
    • The findings suggest a causal link between ethambutol and hyperuricemia-related joint complications.