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Bovine pituitary intraglandular colloid: a transport medium
Acta Biologica Hungarica
|January 1, 1983
Summary
Bovine pituitary colloid, containing hormone fragments, forms in the pituitary and enters the cerebrospinal fluid. This colloid shares protein similarities with cerebrospinal fluid, suggesting a direct pathway for pituitary hormone transfer.
Area of Science:
- Neuroscience
- Endocrinology
- Biochemistry
Background:
- Bovine pituitary intraglandular colloid originates from the degeneration of cells within the intermediate lobe.
- This colloid accumulates in the intraglandular lumen, which connects to the subarachnoid cerebrospinal fluid space via specific channels.
Purpose of the Study:
- To investigate the composition and origin of bovine pituitary intraglandular colloid.
- To determine the relationship between pituitary colloid and cerebrospinal fluid (CSF).
Main Methods:
- Analysis of bovine pituitary intraglandular colloid using acrylamide gel electrophoresis.
- Comparison of protein bands in colloid with those in bovine and human CSF.
Main Results:
- Electrophoresis revealed double protein bands in the gamma region for pituitary colloid.
- These bands are identical to proteins found in bovine and human CSF, though less concentrated in normal CSF.
Conclusions:
- Bovine pituitary colloid contains specific protein components also present in CSF.
- Pituitary colloid, rich in pituitary hormone fragments, is released from the pituitary into the CSF through the identified channels.