Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bleomycin pulmonary toxicity: its relationship to renal dysfunction.

A G Dalgleish, R L Woods, J A Levi

    Medical and Pediatric Oncology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Inflammation and late-life depressive symptoms.

    medRxiv : the preprint server for health sciences·2026
    Same author

    Higher testosterone is associated with higher HDL-cholesterol and lower triglyceride concentrations in older women: an observational study.

    Climacteric : the journal of the International Menopause Society·2024
    Same author

    Low-dose aspirin and incident atrial fibrillation in healthy older individuals: a post-hoc analysis of the ASPREE trial.

    European heart journal. Cardiovascular pharmacotherapy·2023
    Same author

    Self-reported oral health status, edentulism and all-cause mortality risk in 12 809 Australian older adults: a prospective cohort study.

    Australian dental journal·2023
    Same author

    Compliance-Adjusted Estimates of Aspirin Effects Among Older Persons in the ASPREE Randomized Trial.

    American journal of epidemiology·2023
    Same author

    The relationship between long-term blood pressure variability and cortical thickness in older adults.

    Neurobiology of aging·2023
    Same journal

    Kaposiform hemangioendothelioma and therapy with interferon-alpha.

    Medical and pediatric oncology·2003
    Same journal

    Importance of informed consent in offering to return research results to research participants.

    Medical and pediatric oncology·2003
    Same journal

    Tumor lysis syndrome and neuroblastoma.

    Medical and pediatric oncology·2003
    Same journal

    High incidence of brain tumors of childhood in Hungary between 1989 and 2001.

    Medical and pediatric oncology·2003
    Same journal

    Surviving childhood cancer: what next? Issues under consideration at the After Completion of Therapy (ACT) clinic in India.

    Medical and pediatric oncology·2003
    Same journal

    Local control in childhood extremity sarcomas: salvaging limbs and sparing function.

    Medical and pediatric oncology·2003
    See all related articles

    Bleomycin pulmonary toxicity is linked to renal dysfunction. Checking kidney function before bleomycin (chemotherapy drug) administration and adjusting doses may reduce severe side effects.

    Area of Science:

    • Oncology
    • Nephrology
    • Pulmonology

    Background:

    • Bleomycin is an antineoplastic agent used in cancer treatment.
    • Pulmonary toxicity is a known, serious side effect of bleomycin therapy.
    • The specific risk factors for bleomycin-induced pulmonary toxicity require further elucidation.

    Purpose of the Study:

    • To investigate the association between renal dysfunction and bleomycin-induced pulmonary toxicity.
    • To identify key factors contributing to the development of pulmonary complications in patients treated with bleomycin.

    Main Methods:

    • Retrospective analysis of 275 patients who received bleomycin.
    • Assessment for clinical and laboratory evidence of pulmonary toxicity.
    • Evaluation of renal function and other potential risk factors.

    Related Experiment Videos

    Main Results:

    • Twenty-six patients (9.5%) developed bleomycin pulmonary toxicity.
    • Twenty out of 26 patients (77%) with pulmonary toxicity also had renal dysfunction.
    • Renal dysfunction was identified as a significant factor in developing pulmonary toxicity, independent of other known risk factors.

    Conclusions:

    • Renal dysfunction is a critical factor in the development of bleomycin pulmonary toxicity.
    • Routine monitoring of renal function is recommended before each bleomycin dose.
    • Dose modification based on renal function may mitigate bleomycin-related morbidity and mortality.