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[Substance P].

P Cesaro

    Revue Neurologique
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Substance P (SP), a neuropeptide, is widely distributed in the nervous system and influences various physiological functions. Its precise role remains under investigation, but SP is implicated in pain, motor control, and autonomic regulation.

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    Area of Science:

    • Neuroscience
    • Biochemistry

    Context:

    • Substance P (SP) is an 11-amino acid neuropeptide belonging to the tachykinin family.
    • SP is extensively distributed throughout the peripheral and central nervous systems, with notable concentrations in sensory neurons, basal ganglia, and brain stem.

    Purpose:

    • To elucidate the distribution and potential physiological roles of Substance P.
    • To understand the complex synaptic actions and prolonged duration of action of SP.

    Summary:

    • SP is found in both peripheral and central nervous systems, particularly in sensory pathways and motor control centers.
    • It exhibits complex pre- and post-synaptic effects, often acting as an activating factor with a prolonged duration of action.
    • Potential roles include modulation of nociception, autonomic functions, motor regulation, and developmental processes.

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    Impact:

    • SP's involvement in peripheral nociception (edema, plasma extravasation) and central pain modulation (analgesia) highlights its significance in pain pathways.
    • Its role in regulating vegetative functions, motor actions, and potentially learning and neural development suggests broad physiological importance.