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Related Experiment Videos

Pain in multiple sclerosis.

D B Clifford, J L Trotter

    Archives of Neurology
    |December 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Clinically significant pain affects nearly 30% of multiple sclerosis (MS) patients. Understanding MS pain pathophysiology and using antidepressants effectively are key for successful chronic pain management.

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    Area of Science:

    • Neurology
    • Pain Medicine
    • Clinical Research

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Pain is a common and debilitating symptom in MS patients.
    • Effective management of MS-related pain is crucial for patient quality of life.

    Purpose of the Study:

    • To determine the incidence of clinically significant pain in a cohort of MS patients.
    • To highlight the importance of understanding pain pathophysiology in MS.
    • To emphasize the role of specific pharmacotherapies in managing MS pain.

    Main Methods:

    • Retrospective review of 317 patients diagnosed with multiple sclerosis.
    • Analysis of patient records to identify and quantify clinically significant pain.

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  • Exclusion of headache and paresthesia from the primary pain incidence calculation.

    • Main Results:

    • The incidence of clinically significant pain, excluding headache and paresthesia, was found to be 28.8% in the studied MS population.
    • This finding underscores the prevalence of non-headache, non-paresthesia pain syndromes in MS.
    • The study identified a need for targeted pain management strategies.

    Conclusions:

    • A significant proportion of multiple sclerosis patients experience clinically significant pain.
    • Effective treatment necessitates a thorough understanding of the underlying pathophysiology of MS pain.
    • Antidepressant medications show particular promise for managing chronic pain in multiple sclerosis patients.