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[Effect of an imidazobenzodiazepine (RO 15-1788) on aggressive behavior in mice]
Abstract:
Imidazobenzodiazepine (Ro 15-1788, 5 mg/kg) similarly to a lose dose of apomorphine (0.1 mg/kg) decreased the intensity of footshock aggression in male rats. Ro 15-1788 significantly potentiated the antiaggressive action of apomorphine. Pirenperone (0.01 mg/kg) potentiated the effect of both drugs, whereas haloperidol (0.01 mg/kg) had an opposite action. After long-term treatment with apomorphine and Ro 15-1788 the tolerance to their antiaggressive action developed. This change was in agreement with increased serotonin metabolism in the forebrain. Unlike the action on aggressive behavior, Ro 15-1788 similarly to haloperidol (0.05 mg/kg) decreased the motor depressant effect of apomorphine (0.01 mg/kg) in mice. This effect correlated with the lowered serotonin metabolism after Ro 15-1788 administration. Unlike apomorphine, Ro 15-1788 reversed catalepsy induced by haloperidol (0.25 mg/kg). Administration of pirenperone (0.03 mg/kg) and destruction of serotoninergic terminals by p-chloroamphetamine (2 X 15 mg/kg) significantly potentiated the sedative action of apomorphine. It appears that different action of Ro 15-1788 on behavioral effects of apomorphine is related to different influence of Ro-1788 on serotoninergic processes in the striatum and limbic structures.
Insights
Imidazobenzodiazepine (Ro 15-1788) and apomorphine reduce aggression in rats. Ro 15-1788 also impacts motor activity and catalepsy, suggesting complex interactions with serotonin pathways.
Area of Science:
- Neuropharmacology
- Behavioral Neuroscience
- Serotonin System Research
Context:
- Aggression and motor behaviors are modulated by complex neurochemical interactions.
- Dopaminergic and serotonergic systems play critical roles in regulating these behaviors.
- Benzodiazepine derivatives, like imidazobenzodiazepines, can interact with neurotransmitter systems.
Purpose:
- To investigate the anti-aggressive effects of imidazobenzodiazepine (Ro 15-1788) and apomorphine in male rats.
- To examine the influence of Ro 15-1788 on apomorphine-induced motor depressant and cataleptic effects in mice.
- To explore the role of serotonin metabolism in the observed behavioral changes.
Summary:
- Imidazobenzodiazepine (Ro 15-1788) and apomorphine reduced footshock-induced aggression in rats, with Ro 15-1788 potentiating apomorphine's anti-aggressive action.
- Tolerance to the anti-aggressive effects developed with long-term treatment, correlating with increased forebrain serotonin metabolism.
- Ro 15-1788 decreased apomorphine's motor depressant effects in mice, linked to lowered serotonin metabolism, and reversed haloperidol-induced catalepsy.
Impact:
- This study highlights the differential effects of Ro 15-1788 on apomorphine's behavioral actions, potentially mediated by distinct influences on serotonergic processes in specific brain regions.
- Findings contribute to understanding the neurobiological underpinnings of aggression and motor control.
- Provides insights into the complex interplay between benzodiazepine and dopaminergic systems and their modulation by serotonin.