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A simple screening test for acute pancreatitis.

P J Holdsworth, A D Mayer, D H Wilson

    The British Journal of Surgery
    |December 1, 1984
    PubMed
    Summary
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    A new urinary test strip for amylase (Rapignost-Amylase) shows potential for screening acute pancreatitis. This test accurately identified patients with high plasma amylase levels, aiding in early diagnosis.

    Area of Science:

    • Clinical Chemistry
    • Diagnostic Medicine
    • Gastroenterology

    Background:

    • Acute pancreatitis diagnosis relies heavily on elevated plasma amylase levels.
    • Accurate and rapid diagnostic tools are crucial for timely intervention in acute abdominal pain.
    • Current diagnostic methods may present limitations in specific clinical scenarios.

    Purpose of the Study:

    • To evaluate the diagnostic performance of the Rapignost-Amylase urinary test strip.
    • To compare the urinary amylase test strip with plasma amylase assays in patients with acute abdominal conditions.
    • To assess the utility of the Rapignost-Amylase test in screening for clinically occult acute pancreatitis.

    Main Methods:

    • Prospective study comparing a urinary amylase test strip (Rapignost-Amylase) with plasma amylase assays.

    Related Experiment Videos

  • Samples of urine and plasma were collected from 23 patients with acute pancreatitis and 38 with other causes of acute abdominal pain.
  • Plasma amylase levels were measured, and Rapignost-Amylase test results were recorded.

    • Main Results:

    • All patients with plasma amylase >1200 IU/l (23 with pancreatitis, 1 with perforated duodenal ulcer) were Rapignost-Amylase positive.
    • Twenty-nine patients tested Rapignost-Amylase negative.
    • Eight "false positives" were observed with plasma amylase levels ranging from 86-474 IU/l.

    Conclusions:

    • The Rapignost-Amylase urinary test strip demonstrates potential as a screening tool for acute pancreatitis.
    • The test shows high sensitivity for elevated plasma amylase levels indicative of pancreatitis.
    • Further evaluation may be warranted to refine its role in diagnosing clinically occult pancreatitis.