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Anaphylactic reaction to aprotinin despite negative ocular sensitivity tests
British Medical Journal (Clinical Research Ed.)
|November 3, 1984
Summary
Aprotinin eye drops may not predict anaphylaxis. A patient had a severe reaction to intravenous aprotinin despite negative eye tests, highlighting risks of this drug.
Area of Science:
- Pharmacology
- Immunology
- Gastroenterology
Background:
- Aprotinin is a drug used to inhibit proteases.
- Endoscopic retrograde pancreatography (ERP) is a procedure used to diagnose and treat pancreatic and biliary conditions.
Observation:
- A patient with a history of pancreatitis received intravenous aprotinin before undergoing ERP.
- The patient had previously shown no sensitivity to aprotinin eye drops.
Findings:
- Despite negative ocular sensitivity tests, the patient experienced a severe anaphylactic reaction upon intravenous administration of aprotinin.
- This suggests that ocular sensitivity tests may not accurately predict systemic anaphylactic reactions to aprotinin.
Implications:
- Clinicians should exercise caution when administering intravenous aprotinin, even in the absence of prior sensitivity.
- Further research is needed to determine reliable methods for predicting anaphylactic reactions to aprotinin.
- Alternative diagnostic or therapeutic approaches may be considered for patients at risk of anaphylaxis.