[Effect of bleomycetin on the proliferative activity of bone marrow and lymph node cells in SJL/J mice]

Dynamics of dose and time dependence of bleomycin action on bone marrow and lymph node cells of SJL/J mice has shown that 6 h after administration of 25 micrograms of bleomycin the proliferative activity is 1.5 times reduced. The antibiotic influences the interphase cells and delays a cellular cycle. A durable and persistent decrease of the proliferative activity (up to 10 days) of bone marrow and lymph node cells shows a prolonged action of the bleomycin single dose and a pronounced cytostatic effect of the antibiotic on cellular elements of SJL/J mice. Bleomycetin is established to produce action both on lymph node and bone marrow tumour cells of SJL/J mice.