Somatic growth and developmental functioning in children receiving prolonged home total parenteral nutrition

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Published on: February 15, 2018

C W Ralston, M J O'Connor, M Ament

    The Journal of Pediatrics
    |November 1, 1984
    PubMed

    Insights

    Children on long-term total parenteral nutrition (TPN) showed normalized growth by age two. Most achieved average or above average developmental performance by 18 months, though two experienced developmental slowing.

    Area of Science:

    • Pediatrics
    • Nutrition Science
    • Developmental Psychology

    Background:

    • Prolonged home total parenteral nutrition (TPN) is a critical intervention for infants with intestinal failure.
    • Long-term outcomes regarding growth and neurodevelopment in TPN-dependent children require further investigation.

    Purpose of the Study:

    • To longitudinally assess somatic growth and psychomotor development in infants receiving home TPN.
    • To evaluate developmental trajectories from infancy to three years of age in this cohort.

    Main Methods:

    • Longitudinal study design tracking nine infants receiving home TPN.
    • Assessment of somatic growth and psychomotor development from infancy to three years of age.

    Main Results:

    • Normalization of somatic growth was achieved by two years of age in all participants.
    • Three children maintained average or above average developmental performance throughout the study.
    • Four children showed initial developmental delays but reached average or above average scores by 18 months.
    • Two children experienced a gradual decline in developmental rate, functioning in the below average to mildly retarded range by three years.

    Conclusions:

    • Home TPN can support normalized somatic growth in infants.
    • While most TPN-dependent children achieve adequate neurodevelopment, a subset may experience developmental slowing.
    • Further research is needed to identify factors influencing developmental outcomes in children on long-term TPN.

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