Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Collagen age and platelet aggregation.

C Brooks, E R Simons

    Gerontology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Platelet aggregation depends on collagen fibril formation time. Younger collagen forms fibrils faster, initiating quicker platelet aggregation, while older collagen shows impaired aggregation ability.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Establishing a National SABR Service: A Model for Safe and Effective Clinical Implementation.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2025
    Same author

    Validity of the brief executive-function assessment tool in an outpatient substance use disorder setting.

    Applied neuropsychology. Adult·2024
    Same author

    Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis.

    bioRxiv : the preprint server for biology·2023
    Same author

    Using general practice clinical information system data for research: the case in Australia.

    International journal of population data science·2021
    Same author

    Household dampness and microbial exposure related to allergy and respiratory health in Danish adults.

    European clinical respiratory journal·2020
    Same author

    Large-for-gestational age diagnosed during second-trimester anatomy ultrasound and association with gestational diabetes and large-for-gestational age at birth.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2019
    Same journal

    Nature-based Virtual Reality for Depression in Alzheimer's Disease: Protocol of a Pilot Randomized Controlled Trial.

    Gerontology·2026
    Same journal

    A Pilot Study of a Multicomponent Interventions in Acute Geriatric Care: Effects on Functional Outcomes and Mobility.

    Gerontology·2026
    Same journal

    Geriatrics co-management of the vulnerable older surgical patient.

    Gerontology·2026
    Same journal

    Title: Same Day Discharge in Primary Total Joint Arthroplasty in Octogenarians: A Case Series and Narrative Review of Optimization Strategies and Perioperative Outcomes.

    Gerontology·2026
    Same journal

    Emotional Reactivity to Daily Physical Symptoms in Adulthood and Old Age: The Role of Different Facets of Social Support.

    Gerontology·2026
    Same journal

    Sex Differences in the Development of a Multidimensional Fall Risk Index for Older Adults.

    Gerontology·2026
    See all related articles

    Area of Science:

    • Biochemistry
    • Biomaterials Science
    • Hematology

    Background:

    • Platelet aggregation is crucial for hemostasis.
    • Collagen is a primary initiator of platelet aggregation in vivo.
    • The physical properties of collagen, such as fibril formation, may influence its pro-aggregatory activity.

    Purpose of the Study:

    • To investigate the relationship between collagen fibril formation and platelet aggregation.
    • To determine the role of collagen age and fibril characteristics in initiating platelet aggregation.

    Main Methods:

    • Rat tail tendon collagen was used to initiate platelet aggregation.
    • Collagen fibril formation rates and lag times were measured.
    • Platelet aggregation was assessed using preformed collagen fibrils of varying ages and sizes.

    Related Experiment Videos

    Main Results:

    • Collagen-initiated platelet aggregation shows a collagen age-dependent lag time.
    • This lag time is inversely related to the rate of collagen fibril formation.
    • Preformed collagen fibrils (45-90 A diameter) induced identical platelet aggregations regardless of collagen age.
    • Fibrils formed after prolonged incubation (≥20 min) exhibited impaired platelet aggregating ability.

    Conclusions:

    • The size and formation time of collagen fibrils are critical determinants of platelet aggregation.
    • Collagen age influences platelet aggregation primarily through its effect on fibril formation kinetics.
    • Optimized collagen fibril characteristics are necessary for maximal platelet aggregating potential.