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Glomerular and postglomerular permselectivity to anionic dextrans in the dog.

C Whiteside, M Silverman

The American Journal of Physiology

|December 1, 1984

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Glomerular capillaries limit anionic dextran passage, unlike postglomerular capillaries, which show increased permeability to anionic dextrans compared to neutral ones. This study investigated kidney capillary permselectivity using multiple-indicator-dilution techniques.

Area of Science:

Renal physiology and microcirculation.
Capillary permselectivity and solute transport.
Kidney function and filtration dynamics.

Background:

Understanding glomerular and postglomerular capillary function is crucial for kidney health.
The charge and size selectivity of these capillaries influence solute filtration and reabsorption.
Previous studies suggest differences in how anionic and neutral molecules traverse renal capillaries.

Purpose of the Study:

To investigate the permselectivity of glomerular and postglomerular capillaries to anionic dextran markers.
To compare the passage of anionic dextrans versus neutral dextrans across different renal capillary beds.
To assess the influence of renal plasma flow on capillary extraction of these markers.

Main Methods:

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Employed the multiple-indicator-dilution (MID) technique in anesthetized dogs.

Injected a bolus of sulfated [3H]dextran (anionic), [125I]albumin, [14C]inulin, and creatinine into the renal artery.

Collected serial samples of renal venous and urine outflows to determine marker recovery and extraction.

Main Results:

Glomerular extraction of anionic dextrans was 30-50% lower than neutral dextrans of similar size, indicating charge-based limitation.
Postglomerular capillary extraction of anionic dextrans varied inversely with renal plasma flow, suggesting diffusion limitation.
The permeability-surface area product for anionic dextrans was higher than for neutral dextrans in postglomerular capillaries.

Conclusions:

Glomerular capillaries exhibit charge-dependent selectivity, restricting the passage of anionic solutes.
Postglomerular capillaries demonstrate increased apparent permeability to anionic dextrans relative to neutral dextrans.
Renal capillary permselectivity differs significantly between the glomerular and postglomerular microvasculature.