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Differential distribution of tolerogenic bovine gamma-globulin in lymphoid tissues
Deaggregated, tolerogenic bovine gamma-globulin was traced after intravenous injection into DDD mice. Amount of organ-distributed tolerogen varied among lymphoid organs such as spleen, thymus, axillary lymph node and femur bone marrow, probably depending on the amount of blood supply. On the other hand, the tolerogen elimination rate (TER) in these organs was almost the same as TER in blood, the half life being 2.6 days. Although the TER of tissue-associated tolerogen and of cell-associated tolerogen were also almost the same as that in blood, relative amount of cell-associated tolerogen differed among organs, the antigen amounts being 77 times higher in lymph node cells and 4 times higher in spleen and bone marrow cells than in thymus cells. These results are discussed in relation to the difference in the tolerance inducibility among lymphoid organs reported previously.
Deaggregated, tolerogenic bovine gamma-globulin was traced after intravenous injection into DDD mice. Amount of organ-distributed tolerogen varied among lymphoid organs such as spleen, thymus, axillary lymph node and femur bone marrow, probably depending on the amount of blood supply. On the other hand, the tolerogen elimination rate (TER) in these organs was almost the same as TER in blood, the half life being 2.6 days. Although the TER of tissue-associated tolerogen and of cell-associated tolerogen were also almost the same as that in blood, relative amount of cell-associated tolerogen differed among organs, the antigen amounts being 77 times higher in lymph node cells and 4 times higher in spleen and bone marrow cells than in thymus cells. These results are discussed in relation to the difference in the tolerance inducibility among lymphoid organs reported previously.