Mezlocillin dose dependent elimination kinetics in renal impairment

The effect of drug dose on mezlocillin elimination kinetics was examined in six subjects with normal renal function and in six anuric patients. Each subject received mezlocillin 1,3 and 5 g as single intravenous doses separated by one week. Elimination was not prolonged by increasing the dose in subjects with normal renal function, but elimination kinetics were dose dependent in anuric patients. Therapeutic guidelines are suggested.