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Basal cell tumor with eccrine differentiation (eccrine epithelioma).

N P Sánchez, R K Winkelmann

    Journal of the American Academy of Dermatology
    |April 1, 1982
    PubMed
    Summary

    Eccrine epithelioma is a rare, infiltrating basaloid tumor often found on the scalp. Its differentiation toward eccrine structures contributes to its recurrent, locally invasive nature.

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    Area of Science:

    • Dermatopathology
    • Oncology

    Background:

    • Basal cell tumors with eccrine differentiation were first reported in 1969.
    • This study emphasizes the characteristics of this rare tumor based on new and existing literature.

    Observation:

    • The tumor presents as an infiltrating basaloid growth, typically on the scalp or head.
    • Histologically, it shows basaloid, alveolar, and cystic epithelial masses, with areas resembling morpheaform epithelioma or syringoma.
    • Enzyme studies reveal phosphorylase and focal lysosomal enzymes, alongside acid mucopolysaccharides.

    Findings:

    • Electron microscopy confirms epithelial masses with distinct eccrine duct features.
    • The tumor exhibits a tendency to recur, likely due to incomplete surgical excision.
    • Its differentiation towards eccrine structures is a key characteristic.

    Implications:

    • Eccrine epithelioma can be misdiagnosed as other tumors like basal cell carcinoma or syringoma.
    • Understanding its eccrine differentiation is crucial for predicting its clinical behavior.
    • Accurate diagnosis and adequate excision are vital for managing this locally infiltrative and recurrent tumor.

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