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Related Experiment Videos

Patch tests with killed sonicated microflora in patients with psoriasis.

C W Lober, P W Belew, E W Rosenberg

    Archives of Dermatology
    |May 1, 1982
    PubMed
    Summary

    Patients with psoriasis showed a significant reaction to Malassezia ovalis, unlike healthy controls. This suggests M. ovalis may play a role in triggering psoriasis lesions.

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    Is psoriasis a T-cell disease?

    Experimental dermatology·2000

    Area of Science:

    • Dermatology
    • Microbiology
    • Immunology

    Background:

    • Psoriasis is a chronic inflammatory skin condition.
    • The role of microbial triggers in psoriasis is under investigation.

    Purpose of the Study:

    • To investigate the potential role of Malassezia ovalis and Staphylococcus epidermidis in triggering psoriasis.

    Main Methods:

    • Heat-killed sonicated suspensions of M. ovalis and S. epidermidis were applied to the skin of psoriasis patients and controls.
    • Reactions were assessed clinically and histologically.

    Main Results:

    • All psoriasis patients reacted to M. ovalis, while only 2 controls did.
    • Four psoriasis patients reacted to S. epidermidis; no controls did.
    • Psoriasis-like lesions developed in reacting psoriasis patients.

    Conclusions:

    • Malassezia ovalis appears to be a significant trigger for psoriasis in susceptible individuals.
    • Further research is warranted to elucidate the mechanisms of M. ovalis in psoriasis pathogenesis.

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