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Related Experiment Videos

Does porosity matter?

G D Smellie

    The Journal of Cardiovascular Surgery
    |May 1, 1982
    PubMed
    Summary

    Knitted aortic aneurysmectomy grafts show reduced thromboembolic activity compared to woven grafts. This suggests knitted prostheses may offer better long-term patency and fewer complications in patients.

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    Area of Science:

    • Vascular Surgery
    • Biomaterials Science
    • Cardiovascular Research

    Background:

    • Aortic aneurysmectomy prostheses, while successful, remain thrombogenic.
    • Current woven and knitted grafts do not develop endothelial linings in humans.
    • Thrombogenicity and micro-emboli formation are key concerns for long-term graft patency.

    Purpose of the Study:

    • To compare the thrombogenicity of woven versus knitted aortic grafts.
    • To assess the long-term performance of different graft materials.
    • To evaluate the risk of thromboembolic events associated with aortic prostheses.

    Main Methods:

    • Patients surviving at least four years post-aortic aneurysmectomy were studied.
    • Grafts were categorized as either woven or knitted fabric.
    • Persistence of distal pulses was used as an index for thrombogenicity and micro-emboli formation.

    Main Results:

    • A statistically significant difference was observed in distal pulse persistence.
    • Knitted grafts demonstrated better pulse persistence in the 5th, 6th, and 7th years.
    • This suggests lower thromboembolic activity in knitted grafts compared to woven ones.

    Conclusions:

    • Knitted aortic grafts appear less prone to thromboembolic activity than woven grafts.
    • The findings suggest potential advantages of knitted prostheses for long-term patient outcomes.
    • Further research into graft material properties and endothelialization is warranted.

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