Role of lipoxygenases in regulation of PHA and phorbol ester-induced mitogenesis

The experiments described here confirm the critical involvement of products of arachidonic acid metabolism in immune cell function. The results suggest opposing activities of the cyclo-oxygenase versus the lipoxygenases products in these systems. However, in contrast to the situation with the prostaglandins, where addition of the pure compounds has reproduced the effects predicted from the inhibitor studies, identification of the specific lipoxygenase products involved and the induction of the predicted biological response by addition of these compounds remains to be accomplished.