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Laparoscopy--a stressful procedure.

G M Cooper, A M Scoggins, I D Ward

    Anaesthesia
    |March 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This study examined metabolic and hormonal changes during laparoscopy using fentanyl or Althesin anesthesia. Both anesthesia methods caused similar increases in cortisol and prolactin levels, with no significant differences observed.

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    Area of Science:

    • Anesthesiology
    • Endocrinology
    • Surgical Metabolism

    Background:

    • Laparoscopic procedures trigger significant physiological stress.
    • Understanding the metabolic and hormonal responses to anesthesia is crucial for patient management.

    Purpose of the Study:

    • To investigate and compare the metabolic and hormonal effects of fentanyl and Althesin as supplementary anesthesia during nitrous oxide-oxygen anesthesia for laparoscopy.

    Main Methods:

    • Twenty-two patients undergoing laparoscopy were studied.
    • Anesthesia was maintained with nitrous oxide-oxygen, supplemented by either fentanyl or Althesin.
    • Plasma cortisol, prolactin, and blood glucose levels were measured preoperatively, at the end of laparoscopy, and one hour postoperatively.

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    Main Results:

    • Both anesthetic techniques led to significant increases in plasma cortisol and prolactin levels at the end of laparoscopy, sustained into the recovery period.
    • Althesin group showed a significant increase in blood glucose at the end of laparoscopy and one hour postoperatively.
    • Fentanyl group exhibited a significant increase in blood glucose only during the recovery period.
    • No significant differences were found in the overall metabolic and hormonal changes between the two anesthetic methods.

    Conclusions:

    • Fentanyl and Althesin supplementation during nitrous oxide-oxygen anesthesia for laparoscopy induce comparable metabolic and hormonal stress responses.
    • Both anesthetic regimens appear to be safe concerning these specific hormonal and metabolic markers in the short term.