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Lymphocyte function in anergic patients.

H N Rode, N V Christou, O Bubenik

Clinical and Experimental Immunology

|January 1, 1982

Summary

This summary is machine-generated.

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Surgical patients with anergy, a state of immune unresponsiveness, show normal in vitro lymphocyte responses. However, an in vivo block in lymphocyte activation may explain their increased sepsis risk.

Area of Science:

Immunology
Surgical Pathology

Background:

Anergic surgical patients face heightened risks of sepsis and mortality.
Understanding lymphocyte function is crucial for managing these risks.

Purpose of the Study:

To investigate lymphocyte function in anergic surgical patients.
To identify potential immune defects contributing to sepsis risk.

Main Methods:

Assessed in vitro lymphocyte proliferation using mixed leucocyte culture and purified protein derivative (PPD).
Evaluated the in vivo reactivity of activated lymphocytes by intradermal injection into patients.
Correlated in vitro proliferation with in vivo skin test responses.

Main Results:

Over 80% of patients exhibited normal in vitro lymphocyte responses in mixed leucocyte cultures.

Related Experiment Videos

56% of lymphocytes showed a positive in vitro proliferative response to PPD.

In vitro-activated lymphocytes elicited positive skin reactions in 79% of patients when PPD was present, contrasting with <20% without PPD or antigen.

Conclusions:

Anergic surgical patients may possess an acquired immune defect characterized by an in vivo blockade of lymphocyte activation.
This defect could underlie the increased susceptibility to sepsis and mortality in this patient group.