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Related Experiment Videos

Captopril-induced skin eruptions.

J R Luderer, D P Lookingbill, D W Schneck

    Journal of Clinical Pharmacology
    |April 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Captopril, an enzyme inhibitor for hypertension, can cause skin rashes and other symptoms in some patients. These reactions often resolve even with continued captopril use.

    Area of Science:

    • Pharmacology
    • Dermatology
    • Nephrology

    Background:

    • Hypertension management often involves converting enzyme inhibitors.
    • Captopril is an orally active angiotensin-converting enzyme (ACE) inhibitor.

    Observation:

    • A pruritic, erythematous, macular, and papular eruption developed in seven of 23 hypertensive patients treated with captopril.
    • The eruption appeared between one and 31 weeks after starting captopril therapy.
    • Associated symptoms included diarrhea, fever, arthralgias, and in one case, Coombs-positive hemolytic anemia and acute renal failure with eosinophiluria.

    Findings:

    • Skin biopsies showed a perivascular and perifollicular lymphocytic and histiocytic infiltrate.
    • No significant changes in BUN, creatinine, or urinalyses were noted in most patients.

    Related Experiment Videos

  • Transient increases in plasma prostaglandin E were observed in some patients.

    • Implications:

    • Captopril can induce a spectrum of cutaneous and systemic adverse reactions.
    • These reactions may be associated with specific laboratory findings like eosinophilia and eosinophiluria.
    • The findings highlight the importance of monitoring patients for adverse effects during captopril therapy.