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Related Experiment Videos

Suppressor cell activity in progressive systemic sclerosis.

E L Krawitt, G Holdstock, J H Bland

    The Journal of Rheumatology
    |March 1, 1982
    PubMed
    Summary
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    Immune cells producing prostaglandin were elevated in systemic sclerosis patients, suggesting a potential compensatory immune response to fibrogenesis regulation defects.

    Area of Science:

    • Immunology
    • Rheumatology
    • Cell Biology

    Background:

    • Systemic sclerosis is an autoimmune disease characterized by fibrosis.
    • Immunoregulatory abnormalities are implicated in systemic sclerosis pathogenesis.
    • The role of prostaglandin-producing cells in systemic sclerosis is not fully understood.

    Purpose of the Study:

    • To investigate the activity of prostaglandin-producing suppressor cells in patients with progressive systemic sclerosis.
    • To compare this activity with concanavalin-A induced suppressor T cell activity.

    Main Methods:

    • Assessing prostaglandin-producing suppressor cell activity in patients with progressive systemic sclerosis.
    • Measuring concanavalin-A induced suppressor T cell activity in the same patient cohort.

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    Main Results:

    • Significantly increased prostaglandin-producing suppressor cell activity was observed in patients with progressive systemic sclerosis (p < .01).
    • No significant differences in concanavalin-A induced suppressor T cell activity were found between patients and controls.

    Conclusions:

    • The findings indicate an alteration in immunoregulatory function in progressive systemic sclerosis.
    • This alteration may represent a compensatory mechanism for a defect in fibrogenesis regulation.