Related Experiment Videos
Histamine hypersensitivity in mice induced by concanavalin A
The Journal of Allergy and Clinical Immunology
|February 1, 1978
Summary
Concanavalin A and Bordetella pertussis histamine-sensitizing factor (HSF) induce histamine sensitivity similarly in CFW mice but not CFI mice. Differences suggest local adrenergic effects, not systemic imbalance, mediate histamine sensitization.
Area of Science:
- Immunology
- Pharmacology
Background:
- Histamine sensitivity can be induced by various agents.
- Understanding the mechanisms of histamine sensitization is crucial for developing targeted therapies.
Purpose of the Study:
- To compare the effects of concanavalin A (Con A) and Bordetella pertussis histamine-sensitizing factor (HSF) on histamine sensitivity in mice.
- To elucidate the underlying mechanisms of induced histamine sensitivity.
Main Methods:
- Comparison of CFW and CFI mouse responses to Con A and HSF.
- Assessment of induced cutaneous and systemic sensitivities to histamine, serotonin, and epinephrine.
- Evaluation of beta-adrenergic blockade effects.
Main Results:
- Both Con A and HSF induced histamine sensitivity in CFW mice but not CFI mice.
- Both agents required similar sensitization times and induced cutaneous histamine sensitivity.
- Con A failed to induce systemic susceptibility to serotonin or beta-adrenergic blockade, unlike HSF.
- Epinephrine protected against sensitization by both agents.
Conclusions:
- Con A and HSF share common pathways in inducing histamine sensitivity.
- The findings challenge systemic adrenergic imbalance as the sole mechanism, suggesting a role for local adrenergic effects.
- Further research is needed to fully understand the complex mechanisms of histamine sensitization.