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Related Experiment Videos

Periodic alternating skew deviation.

J M Mitchell, J L Smith, R M Quencer

    Journal of Clinical Neuro-Ophthalmology
    |March 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    A rare neuro-ophthalmologic motility pattern, periodic alternating skew deviation, was observed in a patient with a lesion affecting the interstitial nucleus of Cajal. This finding aids in diagnosing specific neurological conditions.

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    Area of Science:

    • Neurology
    • Ophthalmology
    • Neuroscience

    Background:

    • Sudden onset of visual and vestibular symptoms can indicate serious neurological events.
    • Understanding complex eye movement disorders is crucial for accurate neuro-ophthalmologic diagnosis.

    Observation:

    • A 78-year-old hypertensive woman presented with blurred vision, dizziness, gait ataxia, and vertical double vision.
    • Examination revealed a unique motility pattern: periodic alternating skew deviation with downbeat nystagmus.
    • Computed tomography identified a focal lesion at the level of the interstitial nucleus of Cajal.

    Findings:

    • The patient exhibited a previously unreported motility disturbance, periodic alternating skew deviation.
    • This condition was associated with downbeat nystagmus.

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  • A lesion in the interstitial nucleus of Cajal was correlated with the observed motility pattern.

    • Implications:

    • Periodic alternating skew deviation is a novel finding in neuro-ophthalmology.
    • The interstitial nucleus of Cajal is implicated in this specific motility disturbance.
    • Recognition of this pattern aids in the topical diagnosis of brainstem and cerebellar disorders.