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Visual-evoked responses. A new abnormality with focal retinal damage
Journal of Clinical Neuro-Ophthalmology
|December 1, 1981
Summary
A novel visual-evoked response abnormality linked to retinal damage was observed. This finding highlights the importance of ophthalmoscopy in interpreting visual-evoked response abnormalities.
Area of Science:
- Neuroscience
- Ophthalmology
- Oncology
Background:
- Malignant astrocytoma can affect visual pathways.
- Intra-arterial chemotherapy (BCNU) is used for brain tumors.
- Visual-evoked responses (VERs) assess visual pathway function.
Observation:
- A patient with a right parietal malignant astrocytoma treated with BCNU presented with a unique monocular VER abnormality.
- Ophthalmoscopy revealed optic disc blurring and a retinal hemorrhage.
- VERs showed prolonged P-100 wave latency in the ipsilateral occipital area during right eye stimulation.
Findings:
- The observed VER abnormality was ipsilateral to the retinal pathology and chemotherapy treatment.
- This pattern suggests focal retinal damage can cause specific VER alterations.
- Contralateral eye stimulation yielded normal VERs, reinforcing the monocular nature of the abnormality.
Implications:
- VER abnormalities should be correlated with ophthalmoscopic findings.
- Relying solely on VERs without considering retinal pathology can lead to misinterpretation.
- This case expands understanding of VER abnormalities in the context of focal retinal damage and neurological treatment.