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Diffusion within egg lecithin bilayers resembles that within soft polymers.

J M Wolosin, H Ginsburg, W R Lieb

    The Journal of General Physiology
    |January 1, 1978
    PubMed
    Summary
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    Egg lecithin bilayers act like soft polymers, affecting chemical substance permeability based on molecular size. This study analyzes the permeability coefficient/octanol:water partition coefficient ratio for 33 chemicals.

    Area of Science:

    • Biochemistry
    • Physical Chemistry
    • Materials Science

    Background:

    • Cell membranes and artificial bilayers are crucial for understanding drug delivery and biological transport.
    • The relationship between a chemical's properties and its ability to cross membranes is key to predicting its behavior.
    • Egg lecithin bilayers serve as a model system for studying membrane permeability.

    Purpose of the Study:

    • To investigate the relationship between molecular volume and membrane permeability.
    • To determine how egg lecithin bilayers discriminate between chemical substances of varying sizes and shapes.
    • To analyze the permeability coefficient/octanol:water partition coefficient ratio for 33 different chemical substances.

    Main Methods:

    • Calculated the permeability coefficient for 33 chemical substances.

    Related Experiment Videos

  • Determined the octanol:water partition coefficient for the same substances.
  • Analyzed the ratio of these coefficients in relation to the molecular volume of each substance.
  • Utilized egg lecithin bilayers as the model membrane system.

    • Main Results:

    • A correlation was found between the permeability coefficient/octanol:water partition coefficient ratio and molecular volume.
    • Egg lecithin bilayers demonstrated size- and shape-dependent discrimination of chemical permeants.
    • The observed behavior suggests a polymer-like interaction within the bilayer structure.

    Conclusions:

    • Egg lecithin bilayers exhibit properties consistent with soft polymers in their interaction with chemical substances.
    • Molecular size and shape are significant factors influencing the permeability of substances across these lipid bilayers.
    • This finding has implications for understanding membrane transport and designing molecules for specific applications.