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Mezlocillin susceptibility tests by the single-disk agar diffusion method.

R J Fass, R B Prior

Antimicrobial Agents and Chemotherapy

|February 1, 1981

Summary

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A regression line accurately correlates mezlocillin disk diffusion zones with minimal inhibitory concentrations for most Enterobacteriaceae and nonfermenter bacteria. This method shows excellent predictive value, excluding Pseudomonas cepacia.

Area of Science:

Clinical Microbiology
Antimicrobial Susceptibility Testing
Pharmacology

Background:

Accurate determination of antimicrobial susceptibility is crucial for effective treatment.
Disk diffusion assays provide a rapid method for assessing bacterial susceptibility.
Mezlocillin is an important antibiotic used against various bacterial infections.

Purpose of the Study:

To establish a correlation between the zone of inhibition produced by a 75-mug mezlocillin disk and the minimal inhibitory concentration (MIC) of mezlocillin.
To evaluate the utility of this correlation for Enterobacteriaceae and nonfermenter bacteria.

Main Methods:

A regression line was calculated to correlate zone diameters with MIC values.
The study involved testing various species of Enterobacteriaceae and nonfermenter bacteria.

Related Experiment Videos

A 75-mug disk of mezlocillin was used for susceptibility testing.

Main Results:

An excellent correlation (r = -0.96) was observed between zone of inhibition and mezlocillin MIC.
This correlation was consistent across most bacterial species tested.
Pseudomonas cepacia was identified as an exception, showing poor correlation.

Conclusions:

The 75-mug mezlocillin disk diffusion assay is a reliable method for predicting MICs in most Enterobacteriaceae and nonfermenters.
This validated correlation can aid in clinical decision-making for mezlocillin therapy.
Further investigation is needed for Pseudomonas cepacia susceptibility assessment using this method.