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Systemic absorption of clindamycin hydrochloride after topical application
Journal of the American Academy of Dermatology
|August 1, 1982
Summary
Topical clindamycin for acne shows minimal systemic absorption, with no detectable levels in serum. However, urinary excretion indicates some systemic uptake, varying significantly between individuals.
Area of Science:
- Dermatology
- Pharmacokinetics
Background:
- Topical clindamycin is widely used for acne treatment.
- Systemic absorption of topical clindamycin from the skin is not well-established.
Purpose of the Study:
- To quantify systemic absorption of clindamycin after topical application for acne.
- To assess serum levels and urinary excretion of clindamycin during therapy.
Main Methods:
- Thirteen acne patients applied 1% clindamycin hydrochloride topically.
- Serum and urine clindamycin levels were measured on days 3 and 27 of treatment.
Main Results:
- No clindamycin was detected in serum ( < 0.4 microgram/ml).
- Clindamycin was present in the urine of 10 out of 13 patients, with significant intersubject variation.
- Urinary excretion showed a strong correlation between day 3 and day 27 for individuals.
- Average systemic absorption was estimated at 4% to 5%, with higher absorption in some patients.
Conclusions:
- Topical clindamycin for acne results in minimal systemic absorption.
- Urinary excretion confirms systemic uptake, but serum levels remain undetectable.
- Individual absorption rates can vary significantly.