Left ventricular hypertrophy in non-rheumatic myocarditis in children

Related Experiment Video

Updated: Aug 19, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

T Oda, K Hamamoto, H Morinaga

    Japanese Circulation Journal
    |November 1, 1982
    PubMed

    Insights

    Left ventricular hypertrophy (LVH) is common in children with non-rheumatic myocarditis, often appearing later and resolving over time. Echocardiographic measurements did not correlate with electrocardiographic LVH findings.

    Area of Science:

    • Pediatric Cardiology
    • Cardiovascular Research
    • Clinical Electrophysiology

    Background:

    • Non-rheumatic myocarditis is an inflammatory condition affecting the heart muscle in children.
    • Left ventricular hypertrophy (LVH) is a potential complication that requires careful monitoring.
    • Electrocardiography (ECG) is a primary tool for assessing cardiac function in pediatric patients.

    Purpose of the Study:

    • To investigate the prevalence and progression of left ventricular hypertrophy (LVH) in Japanese children diagnosed with non-rheumatic myocarditis.
    • To compare electrocardiographic findings of LVH with echocardiographic measurements of left ventricular posterior wall thickness (LVPWT).
    • To understand the long-term cardiac outcomes in pediatric patients with non-rheumatic myocarditis.

    Main Methods:

    • A cohort of 53 Japanese children with non-rheumatic myocarditis was studied.
    • Left ventricular hypertrophy (LVH) was assessed using electrocardiography (ECG).
    • Echocardiography was employed to measure left ventricular posterior wall thickness (LVPWT) for comparison.

    Main Results:

    • The overall prevalence of electrocardiographic LVH was 30.2% (16 out of 53 patients).
    • LVH was detected during follow-up in most affected patients, not solely at initial diagnosis.
    • LVH resolved in all but two patients during the follow-up period (mean 22.8 months).
    • Only one patient progressed to hypertrophic cardiomyopathy.
    • Left ventricular posterior wall thickness (LVPWT) showed no clear correlation with ECG-diagnosed LVH.

    Conclusions:

    • Electrocardiographic evidence of left ventricular hypertrophy (LVH) is a frequent finding in children with non-rheumatic myocarditis.
    • LVH in this pediatric population often appears transiently and may resolve over time.
    • Echocardiographic assessment of LVPWT did not reliably predict the presence of ECG-defined LVH in this cohort.

    More Related Videos

    Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet09:22

    Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

    Published on: November 4, 2015

    Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

    Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

    Published on: January 20, 2023

    Related Concept Videos

    Mitral Regurgitation I: Introduction01:20

    Mitral Regurgitation I: Introduction

    Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
    Mitral Stenosis I: Introduction01:22

    Mitral Stenosis I: Introduction

    Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
    Rheumatic Heart Disease I: Introduction01:23

    Rheumatic Heart Disease I: Introduction

    Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

    Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

    The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

    Cardiomyopathy IV: Restrictive Cardiomyopathy

    Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...