[Immunodepressive action and effects of medroxyprogesterone acetate on the lymphatic tissue of the rabbit appendix]

The influence of medroxyprogesterone acetate (MPA) on lymphoid tissue of rabbit appendix was investigated. The agent caused a uniform depletion of lymphoid cells, which confirmed the immunodepressive properties of the drug. Other findings suggested a corticoid action of the agent and a possible anticellular activity, interfering with nucleic acid synthesis of proliferating cells.