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Related Experiment Videos

Prolactin response to electroconvulsive therapy.

R Ohman, J Walinder, J Balldin

    Lancet (London, England)
    |October 30, 1976
    PubMed
    Summary
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    Electroconvulsive therapy (ECT) significantly increases prolactin levels in patients with depression. Anesthesia and surgery alone had minimal impact on prolactin, highlighting ECT

    Area of Science:

    • Neuroendocrinology
    • Psychiatry

    Background:

    • Electroconvulsive therapy (ECT) is a treatment for severe depression.
    • The neuroendocrine effects of ECT, particularly on prolactin, are not fully understood.

    Purpose of the Study:

    • To investigate the acute effect of electroconvulsive therapy (ECT) on serum prolactin levels.
    • To differentiate the prolactin response to ECT from the effects of anesthesia and surgery.

    Main Methods:

    • Serum prolactin levels were measured in nine patients with endogenous depression before and after ECT.
    • A control group of four patients undergoing minor gynecological surgery with the same anesthesia was studied.

    Main Results:

    • Eight out of nine patients showed a 10 to 50-fold increase in serum prolactin 15 minutes post-ECT.

    Related Experiment Videos

  • The control group experienced negligible changes in serum prolactin levels due to anesthesia and surgery.

    • Conclusions:

    • Electroconvulsive therapy (ECT) induces a significant and rapid increase in serum prolactin.
    • The observed prolactin surge is primarily attributable to the ECT procedure itself, not the associated anesthesia or surgery.