[Effect of pantogam, nicotinamide, and phenazepam on seizure activity]

Effects of different doses of nicotinamide, pantogam, pnenazepam, and their combined actions on generalized seizures induced by pentylenetetrazole (60-100 mg/kg) were studied in acute experiments on mice. It was shown that pantogam (500 mg/kg) doubled the latent period of seizures, considerably attenuated the intensity of attacks and lethality, whereas given in a dose of 1000 mg/kg it completely prevented the animals' death. Nicotinamide (250-500 mg/kg) increased the latent period of seizures without affecting the intensity of seizures or lethality. Nicotinamide (1000 mg/kg) prevented the development of clonico-tonic attacks and lethality. The antiseizure effects of nicotinamide depended on the time of its injection. Phenazepam (1.4 mg/kg) abolished seizures and in a dose of 0.1-0.7 mg/kg protected the animals from death and considerably relieved seizure manifestations. During combined injections of these compounds, the antiseizure effect was more pronounced and could be attained by decreasing the drug doses.