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Human infections with thymine-requiring bacteria.

R Maskell, O A Okubadejo, R H Payne

    Journal of Medical Microbiology
    |February 1, 1978
    PubMed
    Summary
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    Researchers identified thymine-requiring (thy-) mutants in patients treated with co-trimoxazole. These mutants may be pathogenic, with their survival potentially linked to thymine availability from cell breakdown or bacterial persistence.

    Area of Science:

    • Microbiology
    • Clinical Medicine
    • Pharmacology

    Background:

    • Thymine-requiring (thy-) mutants of pathogenic organisms have been isolated from patients.
    • Co-trimoxazole treatment is a common factor in patients harboring these mutants.

    Purpose of the Study:

    • To investigate the occurrence and potential mechanisms of survival for thymine-requiring mutants in patients.
    • To explore the clinical significance and pathogenicity of these thy- mutants.

    Main Methods:

    • Clinical case review of 16 patients with thy- mutant isolates.
    • Analysis of urine samples for thymine-like compounds.
    • In vitro studies observing mutant growth patterns (satellitism).

    Main Results:

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    • Six patients' urine contained thymine-like compounds supporting thy- mutant growth.
    • Potential sources of thymine include pus cell breakdown or bacterial persistence in tissues.
    • Increased isolation frequency of thy- mutants, possibly due to faster secondary mutations.

    Conclusions:

    • Thymine-requiring mutants may be pathogenic, posing a clinical challenge.
    • Alternative chemotherapy should be considered for patients with these infections.
    • Further research is needed to clarify the clinical significance of thy- mutant infections.