Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonspecific suppressor function in rheumatoid arthritis.

R S Panush

    Journal of Clinical & Laboratory Immunology
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Optimism and coping as determinants of psychosocial adjustment to rheumatoid arthritis.

    Journal of clinical psychology in medical settings·2013
    Same author

    Is Running Associated with Osteoarthritis? An Eight-Year Follow-up Study.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    Acute arthritis in the hospital: comparison of rheumatologic with nonrheumatologic care.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    Controversies and perspectives.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    My son, the chairman.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same author

    The solution should include those physicians providing care that best leads to healthy, satisfied patients.

    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
    Same journal

    Policy and science of FMD control: the stakeholders' contribution to decision making. A call for integrated animal disease management.

    Journal of clinical & laboratory immunology·2006
    Same journal

    An informative case of Graves' disease with implications for schizophrenia.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Increase of circulating CD8+CD57+ lymphocytes after measles infection but not after measles vaccination.

    Journal of clinical & laboratory immunology·2006
    Same journal

    Review: immunomodulatory activity of pregnancy-associated plasma protein-A.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Antibodies to Acinetobacter bacteria and bovine brain peptides, measured in bovine spongiform encephalopathy (BSE) in an attempt to develop an ante-mortem test.

    Journal of clinical & laboratory immunology·2004
    Same journal

    Principles of autoimmune disease: pathogenesis, genetics and specific immunotherapy.

    Journal of clinical & laboratory immunology·2004
    See all related articles

    Patients with rheumatoid arthritis (RA) show increased incubation-sensitive suppressor cell function, indicating a specific immune dysregulation. This heightened suppressor activity impacts B-cell proliferation, contributing to diminished immune responses in RA patients.

    Area of Science:

    • Immunology
    • Rheumatology

    Background:

    • Rheumatoid arthritis (RA) is characterized by impaired cellular immune responses.
    • The role of excessive peripheral blood suppressor function in RA pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate whether diminished immune responses in RA patients are due to excessive peripheral blood suppressor function.
    • To compare suppressor cell function in RA patients versus normal subjects.

    Main Methods:

    • Assessed suppressor cell function using various parameters including incubation sensitivity, adherence, indomethacin sensitivity, and Concanavalin A (Con A) inducibility.
    • Quantitated Tmu and Tgamma cell populations.
    • Evaluated suppressor cell effects on mitogen-stimulated immune responses using a novel simplified assay system.

    Related Experiment Videos

    Main Results:

    • Patients with RA demonstrated significantly increased incubation-sensitive suppressor function.
    • Non-specific suppressor function was generally normal, but individual RA patients showed marked abnormalities.
    • RA patients exhibited increased sensitivity of B-cell proliferation to aggregated IgG-induced T-cell suppressor function.

    Conclusions:

    • Increased incubation-sensitive suppressor function is a key feature of immune dysregulation in rheumatoid arthritis.
    • Specific suppressor cell abnormalities contribute to impaired immune responses and B-cell dysfunction in RA.