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Related Experiment Videos

Lyb3: a B cell surface antigen associated with triggering secretory differentiation.

J D Kemp, J W Rohrer, B T Huber

    Immunological Reviews
    |January 1, 1982
    PubMed
    Summary

    Anti-Lyb3 serum modulates the secretory differentiation of MOPC-315 plasmacytoma cells, impacting immune responses without affecting clonal proliferation. This highlights Lyb3

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    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • BALB/c plasmacytoma MOPC-315 cells are TNP-specific IgA lambda 2-secreting cells.
    • These cells contain presecretory cells expressing the Lyb3 determinant.

    Purpose of the Study:

    • To investigate the role of Lyb3 determinant in MOPC-315 cell differentiation.
    • To determine the effect of anti-Lyb3 serum on MOPC-315 cell secretory differentiation and proliferation.

    Main Methods:

    • Modulation of MOPC-315 cell secretory differentiation using anti-Lyb3 serum.
    • Assessment of helper and suppressor T cell interactions with MOPC-315 cells.

    Main Results:

    • Anti-Lyb3 serum modulates MOPC-315 cell secretory differentiation, not proliferation.
    • Anti-Lyb3 serum can augment or replace T cell-mediated enhancement of secretory differentiation.

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  • Anti-Lyb3 serum counteracts T cell-mediated suppression of secretory differentiation.

    • Conclusions:

    • Lyb3 determinant plays a crucial role in regulating secretory differentiation of MOPC-315 plasmacytoma cells.
    • Anti-Lyb3 serum influences immune responses by targeting secretory differentiation events.