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Leishmaniasis in beige mice.

C E Kirkpatrick, J P Farrell

    Infection and Immunity
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Natural killer cells are crucial for controlling visceral leishmaniasis (Leishmania donovani) but not cutaneous leishmaniasis (Leishmania tropica) in mice. Beige mice, deficient in natural killer cells, failed to clear visceral leishmaniasis.

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    Area of Science:

    • Immunology
    • Parasitology
    • Genetics

    Background:

    • Leishmaniasis presents as cutaneous or visceral forms, caused by protozoal parasites.
    • Beige mice (bg/bg) exhibit impaired natural killer (NK) cell activity, serving as a model for Chédiak-Higashi syndrome.
    • Wild-type and heterozygous beige mice possess normal NK cell activity and are used as controls.

    Purpose of the Study:

    • To investigate the role of natural killer cells in the host response to cutaneous and visceral leishmaniasis.
    • To compare the course of leishmaniasis in beige mice with deficient NK cell activity versus control mice.

    Main Methods:

    • Experimental inoculation of Leishmania tropica (cutaneous) and Leishmania donovani (visceral) into beige (bg/bg) and control (bg/+ and +/+) mice.
    • Monitoring disease progression, parasite load, and immune responses (humoral and cellular).

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  • Assessing the ability of mice to clear parasites over a 56-day observation period.

    • Main Results:

    • Beige mice showed no difference in the course of Leishmania tropica infection compared to controls.
    • All mouse groups mounted similar humoral and cellular immune responses to L. tropica.
    • Beige mice failed to eliminate Leishmania donovani amastigotes from the spleen, unlike controls.
    • Humoral and cellular responses to L. donovani antigen were comparable across all groups.

    Conclusions:

    • Natural killer cells play a significant role in the resolution of visceral leishmaniasis (Leishmania donovani).
    • Natural killer cells do not appear essential for recovery from cutaneous leishmaniasis (Leishmania tropica).
    • NK cell deficiency impacts the ability to clear Leishmania donovani, suggesting a targeted therapeutic role for NK cells.