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[Systemic mezlocillin prophylaxis in elective colon surgery].

M Wenzel, M Walden, M Heinrich

|January 1, 1982

Summary

Prophylactic mezlocillin significantly reduced complications like infections and peritonitis in elective colon surgery patients. This antibiotic prophylaxis also shortened hospital stays without increasing bacterial resistance.

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[Reduction of treatment time for children in the trauma room care : Impact of implementation of an interdisciplinary trauma room concept (iTRAP<sup>S</sup>)].

Der Anaesthesist·2018

Area of Science:

Infectious Diseases
Surgical Oncology
Pharmacology

Background:

Postoperative infections are a significant concern in elective colon surgery.
Prophylactic antibiotics aim to reduce the incidence of surgical site infections and other complications.

Purpose of the Study:

To evaluate the efficacy of prophylactic mezlocillin in reducing infectious complications after elective colon surgery.
To assess the impact of mezlocillin prophylaxis on postoperative hospital stay and bacterial resistance patterns.

Main Methods:

A prospective randomized controlled trial involving 100 patients undergoing elective colon surgery.
Patients received either 2g of intravenous mezlocillin preoperatively and every eight hours postoperatively, or placebo (control group).
Serum and tissue mezlocillin concentrations were measured, alongside postoperative bacterial cultures and clinical outcomes.

Main Results:

The mezlocillin group showed a significantly lower incidence of intra-abdominal complications, peritonitis, urinary tract infections, and wound infections (10% vs. 46% in controls).
Average postoperative hospital stay was reduced from 23 days in controls to 19 days in the mezlocillin group.
No selection of resistant bacterial strains or adverse side-effects were observed.

Conclusions:

Prophylactic mezlocillin is effective in reducing infectious complications following elective colon surgery.
Mezlocillin prophylaxis can lead to shorter hospitalizations without promoting antibiotic resistance.
The study supports the use of mezlocillin as a safe and effective prophylactic agent in this surgical setting.

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