[Changes in the elastic tissue of patients with Down's syndrome]

Two patients with Down's syndrome are reported. A concomitant finding in one of them was psoriasis (not frequent in these patients), anetoderma and unelastic connective tissue nevi. Anetoderma was the only concomitant finding in the other patients. On the basis of these findings the authors feel that besides the "stigmata" referred to, patients with Down's syndrome may present congenital malformation of the elastic fibers. Another objective of this paper is to suggest that every one of these patients should be submitted to a through dermatological investigation having regard to the highly varied and interesting skin changes likely to be disclosed.