Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Constitutional chromosome abnormalities and acute leukemia].

C Turc-Carel, F Mugneret, I Sidaner

    Pathologie-Biologie
    |November 1, 1982
    PubMed
    Summary

    Children with Down syndrome (DS) have a 16-20 times higher risk of acute leukemias (AL). Specific chromosome gains in DS leukemic cells may indicate early-stage development, with chromosome 21 being a potential predisposing factor.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Xq28 duplication including MECP2 in six unreported affected females: what can we learn for diagnosis and genetic counselling?

    Clinical genetics·2016
    Same author

    NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular homogenous group with a poor prognosis.

    Leukemia·2016
    Same author

    Homozygous Truncating Intragenic Duplication in TUSC3 Responsible for Rare Autosomal Recessive Nonsyndromic Intellectual Disability with No Clinical or Biochemical Metabolic Markers.

    JIMD reports·2015
    Same author

    Pregnancy outcomes of prenatally diagnosed Turner syndrome: a French multicenter retrospective study including a series of 975 cases.

    Prenatal diagnosis·2014
    Same author

    A French collaborative survey of 272 fetuses with 22q11.2 deletion: ultrasound findings, fetal autopsies and pregnancy outcomes.

    Prenatal diagnosis·2014
    Same author

    Systematic molecular and cytogenetic screening of 100 patients with marfanoid syndromes and intellectual disability.

    Clinical genetics·2013

    Area of Science:

    • Hematology
    • Genetics
    • Oncology

    Context:

    • Acute leukemias (AL) are significant health concerns in children.
    • Down syndrome (DS) is associated with an increased risk of certain cancers, including AL.
    • Understanding the genetic underpinnings of AL in DS is crucial for early detection and treatment.

    Purpose:

    • To review the association between acute leukemias and constitutional chromosome abnormalities (CCA).
    • To explore the specific chromosomal anomalies in leukemic cells of children with and without DS.
    • To investigate the role of chromosome 21 in the predisposition to AL in DS.

    Summary:

    • Acute leukemias are 16 to 20 times more frequent in children with Down syndrome (DS) compared to those without.
    • While acquired chromosome abnormalities in leukemic cells are similar in DS and non-DS patients, the types differ, with DS showing hyperdiploidy and excess C, F, and G chromosomes.
    • Gain of chromosomes 8, 19, and 22 may characterize early-stage leukemic myeloblasts in DS, and chromosome 21 appears to be a predisposing factor.

    Impact:

    • This review highlights critical genetic factors influencing acute leukemia development in Down syndrome.
    • Identifies specific chromosomal anomalies that could serve as biomarkers for early-stage leukemic myeloblasts in DS.
    • Provides insights into the increased incidence of AL in DS, potentially guiding future research and clinical management strategies.

    Related Experiment Videos