[Present status of primary Gougerot-Sjögren syndrome]

When primary and not part of a systemic autoimmune disease, Sjögren's syndrome has peculiar clinical, serological and genetic features. It exceptionally becomes malignant but evolves to a stage of pseudo-lymphoma. Numerous studies suggest hyperstimulation of B-lymphocytes that would result from destruction of suppressive T-lymphocytes, this destruction in turn being probably due to failure of immune complex clearing by the reticulo-endothelial system.