[Pathogenetic aspects of acute renal insufficiency in experimental acute pancreatitis]

The authors carried out a study of some pathogenic mechanisms related to the development of acute renal failure in animals following pancreatitis-induced shock. The study was made in 110 white rats in which acute pancreatitis was induced experimentally, and the results were compared with those obtained in a control lot of 40 rats. The behaviour of some biochemical parameters was investigated (cathecholamines, acid phosphatases, catepsine, aminoacids and polypeptides), in tissue homogenates (liver, intestine and kidney), and in the serum. Histopathologic changes were also evaluated, which occurred in the intestine, the kidney, the liver and the pancreas. Histopathologic changes in the kidney, and acute renal failure which accompanied them in rats with acute pancreatitis are rather a result of protesic activation in the tissues of the organs involved (especially the intestine and the kidney), and are less the results of enzymatic extension or metastases following pancreatic necrosis.