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Moxalactam therapy for gram-negative bacillary meningitis
Reviews of Infectious Diseases
|November 1, 1982
Summary
Moxalactam effectively treated gram-negative bacillary meningitis caused by enteric bacilli in twenty patients. However, it is not recommended for meningitis caused by Pseudomonas aeruginosa or Acinetobacter.
Area of Science:
- Infectious Diseases
- Neuroscience
- Pharmacology
Background:
- Gram-negative bacillary meningitis is a serious infection.
- Moxalactam is a newer beta-lactam antibiotic with activity against gram-negative bacteria.
Purpose of the Study:
- To evaluate the efficacy and safety of moxalactam in treating gram-negative bacillary meningitis.
Main Methods:
- Twenty patients with gram-negative bacillary meningitis were treated with intravenous moxalactam.
- Clinical and microbiological outcomes were assessed.
- Cerebrospinal fluid drug concentrations were measured.
Main Results:
- Seventeen patients showed good clinical and microbiological responses.
- Most bacterial isolates were susceptible to moxalactam.
- Adequate cerebrospinal fluid concentrations were achieved.
Conclusions:
- Moxalactam is effective as a single-agent therapy for meningitis caused by susceptible enteric gram-negative bacilli.
- Moxalactam is not recommended for meningitis caused by Pseudomonas aeruginosa or Acinetobacter.
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