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Cefoperazone (Cefobid, Pfizer).

J A Lyon

    Drug Intelligence & Clinical Pharmacy
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Cefoperazone, a new antibiotic, shows broad-spectrum activity and unique effectiveness against P. aeruginosa. It is effectively eliminated through bile, aiding biliary tract infection treatment without renal dose adjustment.

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    Area of Science:

    • Microbiology
    • Pharmacology

    Background:

    • Cefoperazone is a novel beta-lactam antibiotic.
    • It exhibits broad-spectrum activity against Gram-positive and Gram-negative bacteria.

    Purpose of the Study:

    • To evaluate the efficacy and safety of cefoperazone.
    • To highlight its unique properties, including activity against P. aeruginosa and biliary excretion.

    Main Methods:

    • Clinical trials in the U.S. were conducted.
    • Efficacy and side effect incidence were assessed.

    Main Results:

    • Cefoperazone demonstrated exceptional activity against P. aeruginosa.
    • High biliary excretion facilitates treatment of biliary tract infections; renal elimination is minimal (20%), obviating dosage adjustments in renal impairment.

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  • Clinical response rates were comparable to moxalactam, cefotaxime, and other cephalosporins.
  • Overall side effect incidence was 14%, with diarrhea (5%) and injection site pain/phlebitis (2%) being most common.

    • Conclusions:

    • Cefoperazone is a promising antibiotic for various infections, particularly those involving biliary tracts and P. aeruginosa.
    • Its favorable pharmacokinetic profile in renal impairment simplifies dosing.
    • Further comparative trials are needed due to high cost and lack of head-to-head data with standard regimens.