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[Cardiac prosthesis].

P Marion

    Presse Medicale (Paris, France : 1983)
    |February 26, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Intrathoracic artificial hearts with external energy sources can sustain animals long-term. Future human implants aim for 6-8 hour autonomy, focusing on miniaturization for improved patient mobility and cardiac replacement.

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    Area of Science:

    • Biomedical Engineering
    • Cardiovascular Research
    • Medical Devices

    Context:

    • Intrathoracic artificial hearts with membrane pumps and extracorporeal energy sources have shown long-term viability in animal models.
    • Previous research focused on pulsed flow systems, demonstrating extended survival without significant biological disturbances.

    Purpose:

    • To outline the next experimental phase for intrathoracic artificial heart implantation in humans.
    • To detail the requirements for a human-compatible artificial heart system, including energy conversion and patient autonomy.
    • To highlight current research trends in miniaturization and the exploration of kinetic pumps.

    Summary:

    • An intrathoracic artificial heart with a membrane pump and external energy source successfully supported a cardiotomized animal for months.

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  • The next step involves human implantation with a 6-8 hour autonomous period, rechargeable via external batteries.
  • Research is advancing miniaturization of components and exploring kinetic pumps for smaller, potentially more efficient artificial hearts.

    • Impact:

    • This research paves the way for clinical trials of artificial hearts, potentially offering a solution for end-stage heart failure.
    • Miniaturization and improved energy systems promise greater patient mobility and quality of life.
    • The development of reliable artificial hearts could reduce the need for biological heart transplantation.